Is G-CSF Dangerous in COVID-19: Why Not Use GM-CSF?
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چکیده
منابع مشابه
G-CSF and GM-CSF in Neutropenia.
G-CSF and GM-CSF are used widely to promote the production of granulocytes or APCs. The U.S. Food and Drug Administration approved G-CSF (filgrastim) for the treatment of congenital and acquired neutropenias and for mobilization of peripheral hematopoietic progenitor cells for stem cell transplantation. A polyethylene glycol-modified form of G-CSF is approved for the treatment of neutropenias. ...
متن کاملG-CSF and GM-CSF in clinical trials.
Hematopoietic growth factors have now been purified, cloned, and produced in bacteria and yeast. Those that are currently in clinical study include erythropoietin, GM-CSF, G-CSF, M-CSF (also called CSF-1), and multi-CSF (also called interleukin 3). Growth factor appear likely to enhance the recovery and function of circulating white cells after standard-dose cancer therapy and high-bone-dose ca...
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JBUON 2017; 22(1): 21 GM-CSF and G-CSF are capable to regulate the maturation of undifferentiated multipotent stem cells into mature granulocytes, macrophages and T cells in the bone marrow. Thereby, clinicians correct neutropenia induced by chemotherapy or radiation routinely with recombinant Gor GM-CSFs in clinical practice. However, relevant studies found that treatment for cancer patients w...
متن کاملGrowth Factors G-CSF and GM-CSF: Clinical Options
The body's immediate response to bacterial infection becomes clinically evident as an inflammatory reaction accompanied by an acute-phase response in the liver and hyperthermia. Activation of the immune system must be counterregulated to curb these processes and to prevent (or at least minimize) damage to the host tissue. The major part of this intricate regulation is performed by the cytokine ...
متن کاملClinical use of subcutaneous G-CSF or GM-CSF in malignancy.
Colony-stimulating factors are glycoproteins that act on hematopoietic cells by binding to specific cell surface receptors and stimulating proliferation, differentiation commitment, and a degree of end-cell functional activation. Granulocyte colony-stimulating factor (G-CSF), produced by monocytes, fibroblasts, and endothelial cells, regulates the production of neutrophils within the bone marro...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 2020
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000512574